A holiday all about drinking and reveling with mobs of strangers — what could go wrong?

First there was Thanksgiving, when some families who gathered for turkey and stuffing also shared the coronavirus, causing cases to spike in some places and further taxing the nation’s already stretched hospitals.

Then there was Christmas weekend, when Americans crowded airports in numbers not seen since the start of the pandemic. Anyone who caught the virus then would probably still be in the incubation phase or just starting to feel symptoms now, so it’s too soon yet to gauge the full impact of people’s Christmas activities.

Now comes New Year’s Eve, an occasion for celebrating in large crowds, often among strangers, drinking and reveling and uttering a primal yell when the clock strikes twelve.

In other words, it’s a holiday tailor-made for superspreader events. And it arrives just as the first cases of a new, more contagious variant of the virus have been detected in the United States, in ways that suggest it is already circulating widely.

“It’s in a small community south of Denver, so it’s reasonable to think that it could already be in New York City,” said Dr. Bill Hanage, an associate professor of epidemiology at the Harvard T.H. Chan School of Public Health.

New Year’s Eve, he said, “risks accelerating the introduction of any variants that are more transmissible into communities, and we have reason to think that those are beginning to emerge.”

The risk of transmission rises with the size of the gathering, of course, but also with the amount of alcohol consumed, Dr. Hanage said.

People who drink “become disinhibited,” he noted, “and when they get disinhibited, they are more likely to engage in risky behavior.”

The safest way to see in the new year is at home, with no one outside your household, Dr. Hanage said, but if people do gather in greater numbers, they can decrease the risk somewhat by doing it outdoors and by wearing masks.

“It doesn’t sound very fun or easy to drink Champagne through,” he said, “but wearing a mask is going to provide another barrier to potential transmission.”

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